DoseVault
Longevity Compound

FOXO4-DRI

Senolytic D-retro-inverso peptide that disrupts FOXO4-p53 to selectively kill senescent cells.

Scientific Overview

FOXO4-DRI is a 30-aa D-retro-inverso peptide developed by Peter de Keizer's lab (Cell, 2017). It disrupts the FOXO4-p53 interaction in senescent cells, restoring p53 nuclear exclusion and triggering apoptosis. Mouse data showed improved fur density, fitness, and renal function. No published human trials; only research-grade material is available.

Key Research Benefits

  • ✓Selective senolysis
  • ✓Restored fitness in aged mice
  • ✓Hair regrowth (mouse studies)

Potential Side Effects

⚠Unstudied in humans
⚠Theoretical immune/cytokine reactions

Research Protocols

Common Dosages

Research only

Not established
N/A

“Pre-clinical; pulsed dosing in mice 5 mg/kg 3x/week”

Note: Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.

Dose Calculator

🧮 Peptide Reconstitution Calculator

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mL

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mcg

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10 Units

or 0.10 mL on a U-100 syringe

Concentration:2.50 mg/mL
Peptide per Unit:25.00 mcg/unit
*Always double-check your calculations. This tool is for educational purposes only.

Explore FOXO4-DRI

Where to source

Vendors with public COAs that stock this category. Affiliate links are disclosed.

  • Limitless Life Nootropics
    FL-based research-peptide supplier with Janoshik third-party COAs and a public affiliate program at ~20%.
    COA: JanoshikAffiliate disclosed
    View vendor →
  • SwissChems
    60+ peptide catalog with Janoshik COAs; weekly affiliate payouts.
    COA: JanoshikAffiliate disclosed
    View vendor →
  • Amino Club
    EU/US-facing vendor with a 20% first-order / 10% recurring affiliate model.
    COA: Third-partyAffiliate disclosed
    View vendor →

FOXO4-DRI by goal

Read FOXO4-DRI's profile filtered through specific research goals.

FOXO4-DRI for SleepFOXO4-DRI for Longevity

Molecular Profile

linear
D-retro-inverso FOXO4 fragment
30 AA Sequence

Quick Reference

Status
Research Compound
Category
Longevity
Common Dosage
Not established
N/A

Strictly for research purposes. Not for human consumption.

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Medical Disclaimer

Information provided on DoseVault is for educational and research purposes only. This website does not advocate for the human use of peptides. Peptides are currently sold as research chemicals and are not FDA-approved for human consumption. Always consult a licensed medical professional before considering any protocol.