TB-500 + IGF-1 LR3 stack
A research-context overview of stacking TB-500 with IGF-1 LR3: the rationale, complementary benefits, side-effect overlap, and pharmacokinetic considerations. Educational only — never a recommendation.
Why this stack?
Pairing a Performance peptide like IGF-1 LR3 with a Recovery peptide like TB-500 is one of the most common stack archetypes in the research literature. The Performance compound drives the GH/IGF-1 axis or anabolic signaling; the Recovery compound shortens the soft-tissue and inflammation tax of training, letting the anabolic signal land on healthier tissue. The two work on independent pathways, so timing concerns are minimal — most researchers dose them on separate clocks.
TB-500
Boosts tissue repair and reduces inflammation, perfect for injury-prone athletes.
Key benefits
- ✓Boosts tissue repair
- ✓Reduces inflammation
- ✓Improves flexibility
- ✓Promotes cell migration
Side effects to watch
- ⚠Headaches (rare)
- ⚠Dizziness (rare)
- ⚠Injection site reaction
IGF-1 LR3
Growth Mediator.
Key benefits
- ✓Muscle hyperplasia
- ✓Fat loss
- ✓Recovery
Side effects to watch
- ⚠Hypoglycemia
- ⚠Gut growth (abuse)
Half-life considerations
TB-500 clears at roughly t½ 2.0 d, while IGF-1 LR3 clears at roughly t½ 1.0 d. Half-lives are within an order of magnitude of each other, so peak windows can overlap if the two compounds are dosed simultaneously. Many researchers stagger by several hours to keep the peak signaling distinct.
Educational use only
This calculator is provided for research and educational purposes. Outputs are derived from the values you enter. Always verify your math and consult a licensed physician before acting on any result.