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Cosmetic Compound

Palmitoyl Pentapeptide-4 (Matrixyl)

Original Matrixyl peptide; signals fibroblasts to upregulate collagen I/III and fibronectin.

Scientific Overview

Palmitoyl Pentapeptide-4 (pal-KTTKS) is the original Matrixyl, developed by Sederma. The palmitoyl chain enhances stratum-corneum penetration; the KTTKS sequence is a procollagen I fragment that feedback-stimulates fibroblast collagen synthesis. Industry placebo-controlled trials show modest wrinkle-depth reduction at 4 ppm over 12 weeks.

Key Research Benefits

  • ✓Collagen I/III synthesis
  • ✓Reduces fine lines
  • ✓Improves skin firmness

Potential Side Effects

⚠Rare contact sensitivity
⚠Topical only

Research Protocols

Common Dosages

Topical

3-8 ppm
Daily AM/PM

“Leave-on serum/cream”

Note: Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.

Dose Calculator

🧮 Peptide Reconstitution Calculator

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Total amount of peptide in the vial.

mL

Volume of water used to mix.

mcg

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10 Units

or 0.10 mL on a U-100 syringe

Concentration:2.50 mg/mL
Peptide per Unit:25.00 mcg/unit
*Always double-check your calculations. This tool is for educational purposes only.

Explore Palmitoyl Pentapeptide-4 (Matrixyl)

Where to source

Vendors with public COAs that stock this category. Affiliate links are disclosed.

  • Limitless Life Nootropics
    FL-based research-peptide supplier with Janoshik third-party COAs and a public affiliate program at ~20%.
    COA: JanoshikAffiliate disclosed
    View vendor →
  • SwissChems
    60+ peptide catalog with Janoshik COAs; weekly affiliate payouts.
    COA: JanoshikAffiliate disclosed
    View vendor →
  • Amino Club
    EU/US-facing vendor with a 20% first-order / 10% recurring affiliate model.
    COA: Third-partyAffiliate disclosed
    View vendor →

Palmitoyl Pentapeptide-4 (Matrixyl) by goal

Read Palmitoyl Pentapeptide-4 (Matrixyl)'s profile filtered through specific research goals.

Palmitoyl Pentapeptide-4 (Matrixyl) for Libido

Molecular Profile

linear
C39H75N7O9
5 AA Sequence

Quick Reference

Status
Research Compound
Category
Cosmetic
Common Dosage
3-8 ppm
Daily AM/PM

Strictly for research purposes. Not for human consumption.

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Medical Disclaimer

Information provided on DoseVault is for educational and research purposes only. This website does not advocate for the human use of peptides. Peptides are currently sold as research chemicals and are not FDA-approved for human consumption. Always consult a licensed medical professional before considering any protocol.