DoseVault
Sleep Compound

Orexin-A (Hypocretin-1)

Hypothalamic neuropeptide regulating wakefulness; intranasal investigation for narcolepsy.

Scientific Overview

Orexin-A (hypocretin-1) is a 33-aa hypothalamic neuropeptide central to wakefulness; loss of orexin neurons causes narcolepsy type 1. Intranasal orexin-A has been studied as a replacement therapy in narcolepsy and for cognitive arousal in sleep deprivation (Baier et al., 2008). Small-molecule orexin agonists (e.g. TAK-861, Takeda) are in late-stage trials.

Key Research Benefits

  • ✓Promotes wakefulness
  • ✓Investigated in narcolepsy type 1
  • ✓Potential cognitive arousal

Potential Side Effects

⚠Insomnia if mistimed
⚠Tachycardia (theoretical)
⚠Limited approved use

Research Protocols

Common Dosages

Research (intranasal)

Not established
Investigational

“Phase 1/2 only”

Note: Dosages listed are common research protocols found in peer-reviewed literature and clinical trials. Individual results and requirements may vary significantly in a research context.

Dose Calculator

🧮 Peptide Reconstitution Calculator

mg

Total amount of peptide in the vial.

mL

Volume of water used to mix.

mcg

Draw to this mark

10 Units

or 0.10 mL on a U-100 syringe

Concentration:2.50 mg/mL
Peptide per Unit:25.00 mcg/unit
*Always double-check your calculations. This tool is for educational purposes only.

Explore Orexin-A (Hypocretin-1)

Where to source

Vendors with public COAs that stock this category. Affiliate links are disclosed.

  • Limitless Life Nootropics
    FL-based research-peptide supplier with Janoshik third-party COAs and a public affiliate program at ~20%.
    COA: JanoshikAffiliate disclosed
    View vendor →
  • SwissChems
    60+ peptide catalog with Janoshik COAs; weekly affiliate payouts.
    COA: JanoshikAffiliate disclosed
    View vendor →
  • Amino Club
    EU/US-facing vendor with a 20% first-order / 10% recurring affiliate model.
    COA: Third-partyAffiliate disclosed
    View vendor →

Orexin-A (Hypocretin-1) by goal

Read Orexin-A (Hypocretin-1)'s profile filtered through specific research goals.

Orexin-A (Hypocretin-1) for SleepOrexin-A (Hypocretin-1) for Libido

Molecular Profile

linear
C152H243N47O44S4
33 AA Sequence

Quick Reference

Status
Research Compound
Category
Sleep
Common Dosage
Not established
Investigational

Strictly for research purposes. Not for human consumption.

Related tools

Medical Disclaimer

Information provided on DoseVault is for educational and research purposes only. This website does not advocate for the human use of peptides. Peptides are currently sold as research chemicals and are not FDA-approved for human consumption. Always consult a licensed medical professional before considering any protocol.