Subcutaneous Injection
Injection into the fat layer beneath the skin
Subcutaneous (SC, SubQ) injection deposits the dose into the adipose layer between the skin and the underlying muscle. Absorption is slower than IM injection but more sustained, which suits the pharmacokinetic profile of most peptide research compounds.
Standard SC sites for peptide research are the abdomen (avoiding the immediate periumbilical zone), the lateral thigh, and the upper outer arm. Site rotation is important: repeatedly injecting the same spot causes localized lipohypertrophy or lipoatrophy that alters absorption.
Most peptides are dosed SC at 90° insertion using a U-100 insulin syringe, with a 4–8 mm needle length depending on the subject’s body composition.
See also
Educational use only
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